Managing chronic lung disease (CLD) via a “treatable traits” approach allows care to tailored to the health needs of the individual. Regional Aboriginal communities have amongst the highest burden of CLD in Australia but providing treatable traits mode...
This project will establish an advanced genomic platform to enhance detection and prevention of bacterial infections in children and young people that cause serious morbidity and, in some cases, mortality, in children and young people. With state-of-th...
Asthma can get worse during pregnancy. Experiencing asthma during pregnancy can have a negative impact on the health of mothers and babies. Babies of asthmatic mothers can have breathing complications and a higher risk of developing asthma later in lif...
Audit of Hunter New England Ear, Nose & Throat Surgical Interventions
An extensive 5-year (2015-2019) database of ENT hospital admissions across HNELHD has been granted to our team to inform future research applications in ear and hearing health of children. Similarly, we have acquired a 5-year (2015-2019) database of E...
Children of Aboriginal and Torres Strait Islander descent experience some of the highest rates of ear disease in the world. Chronic ear disease, known as otitis media with effusion (OME), typically results from an infection in the middle ear causing si...
Kidney stones are a common urinary tract problem that increases the risk of chronic kidney disease later in life. Mouse models, such as the daily administration of glyoxylate intraperitoneally, have been used to understand the pathophysiological change...
Broadly, my PhD research focused on understanding the role of the mammalian immune system in the urinary tract. During my PhD I investigated several immune factors known as cytokines in pre-clinical models of sterile kidney injury resulting from blood ...
Understanding how immune cells repair the kidney after acute kidney injury
A newly discovered type of immune cells termed Group 2 Innate Lymphoid Cells (ILC2s) promote repair of structural cells after injury in multiple sites. The role of these cells in the kidneys is poorly understood; we believe these cells are pivotal in r...
Transcriptome analysis of developing mouse lung following early life infection
Transcriptome essentially refers to a collection of messengers (mRNA) within a cell; when quantified the transcriptome tells us how active genes are in a sample. Using microarray analysis tools, I’ve learnt to critically analyse and interpret alterat...
